November 7th, 2024

New Research Uncovers Genetic Variant’s Alarming Impact on Heart Health and Longevity in Black Americans

New Research Uncovers Genetic Variant’s Alarming Impact on Heart Health and Longevity in Black Americans
Written by Stacy M. Brown

On average, carriers die two to two and a half years earlier than expected. With nearly half a million Black American carriers over the age of 50, the implications are profound.

A groundbreaking study led by researchers at Brigham and Women’s Hospital and Duke University sheds light on the significant health risks posed by the V142I transthyretin variant within the US Black population. Published in the JAMA Network, the study underscores the concerning impact of this genetic variant on heart health and longevity.

“The V142I transthyretin variant, prevalent in three to four percent of self-identified Black individuals in the US, is associated with an increased risk of heart failure and death,” explained lead author Dr. Senthil Selvaraj from Duke University School of Medicine. Drawing from data from over 20,000 self-identified Black individuals, the study estimates that carriers of this variant could collectively lose approximately a million years of life.

The National Newspaper Publishers Association (NNPA) and Pfizer Inc. have been working with partners in various cities in the U.S. to raise awareness of this “serious but under-diagnosed condition that causes heart failure among African Americans and Afro-Caribbeans.” The NNPA is the trade association of the more than 250 African American-owned newspapers and media companies comprising the 197-year-old Black Press of America.

Senior author Dr. Scott D. Solomon, from Brigham and Women’s Hospital and Harvard Medical School, emphasizes the significance of these findings for both clinicians and patients. “We believe these data will inform clinicians and patients regarding risk when these genetic findings are known, either through family screening, medical, or even commercial genetic testing,” he said.

The study revealed that individuals carrying the V142I variant face a substantially elevated risk of heart failure, starting in their 60s, and an increased risk of death, beginning in their 70s. On average, carriers die two to two and a half years earlier than expected. With nearly half a million Black American carriers over the age of 50, the implications are profound.

Transthyretin, a protein in the blood, misfolds when the V142I variant is present. This causes abnormal amyloid protein to build up in the heart and other body parts. This process results in cardiac amyloidosis, a condition characterized by thickening and stiffening of the heart muscle, ultimately leading to heart failure.

Despite the grim outlook, there is hope on the horizon. “There are now several potential new therapies for cardiac amyloidosis, and understanding the magnitude of this risk, at the individual and societal level, will help determine which patients might be best suited for novel therapies,” Dr. Solomon stated.

The study’s comprehensive insights were made possible by pooling data from four NIH-funded studies (ARIC, MESA, REGARDS, and Women’s Health Initiative). “Since 3–4 percent of self-identified Black individuals in the United States carry this variant, a significant number are at elevated risk for developing cardiac amyloidosis, being hospitalized for heart failure, and dying several years earlier than expected,” Dr. Selvaraj added.

With a better understanding of the risks associated with the V142I variant, efforts to raise awareness and facilitate access to treatments will be crucial in improving outcomes for affected individuals. Medical officials said the findings highlight the importance of genetic screening and personalized healthcare interventions in addressing the health disparities faced by the US Black population.

October 16, 2023, HOUSTON, TX – Congressional Candidate Amanda Edwards has raised over $1 million in less than 4 months, a substantial sum that helps bolster the frontrunner status of the former At-Large Houston City Council Member in her bid for U.S. Congress. Edwards raised over $433,000 in Q3 of 2023. This strong Q3 report expands on a successful Q2 where Edwards announced just 11 days after declaring her candidacy that she had raised over $600,000. With over $829,000 in cash-on-hand at the end of the September 30th financial reporting period, Edwards proves again that she is the clear frontrunner in the race. “I am beyond grateful for the strong outpouring of support that will help me to win this race and serve the incredible people of the 18th Congressional District,” said Edwards. “We are at a critical juncture in our nation’s trajectory, and we need to send servant leaders to Congress who can deliver the results the community deserves. The strong support from our supporters will help us to cultivate an 18th Congressional District where everyone in it can thrive.” Edwards said. “Amanda understands the challenges that the hard-working folks of the 18th Congressional District face because she has never lost sight of who she is or where she comes from; she was born and raised right here in the 18th Congressional District of Houston,” said Kathryn McNiel, spokesperson for Edwards’ campaign. Edwards has been endorsed by Higher Heights PAC, Collective PAC, Krimson PAC, and the Brady PAC. She has also been supported by Beto O’Rourke, among many others. About Amanda: Amanda is a native Houstonian, attorney and former At-Large Houston City Council Member. Amanda is a graduate of Eisenhower High School in Aldine ISD. Edwards earned a B.A. from Emory University and a J.D. from Harvard Law School. Edwards practiced law at Vinson & Elkins LLP and Bracewell LLP before entering public service. Edwards is a life-long member of St. Monica Catholic Church in Acres Homes. For more information, please visit www.edwardsforhouston.com

As September 13th rolls around, we extend our warmest birthday wishes to the creative powerhouse, Tyler Perry, a man whose indomitable spirit and groundbreaking work have left an indelible mark on the world of entertainment. With his multifaceted talents as an actor, playwright, screenwriter, producer, and director, Tyler Perry has not only entertained but also inspired audiences worldwide, particularly within the African-American community, where his influence and role have been nothing short of powerful. Born in New Orleans, Louisiana, in 1969, Tyler Perry’s journey to stardom was a path riddled with adversity. Raised in a turbulent household, he found refuge in writing, using it as a therapeutic outlet. This period of introspection gave rise to one of his most iconic creations, Madea, a vivacious, no-nonsense grandmother who would later become a beloved figure in Perry’s works, offering a unique blend of humor and profound life lessons. Despite facing numerous challenges, including rejection and financial struggles, Perry’s determination and unwavering belief in his abilities propelled him forward. In 1992, he staged his first play, “I Know I’ve Been Changed,” which, although met with limited success, was a pivotal moment in his career. Unfazed by initial setbacks, Perry continued to hone his craft, and by 1998, he had successfully produced a string of stage plays that showcased his storytelling prowess.

Calling all teenage student-athletes! If you have dreams of playing college soccer and wish to represent an HBCU, the HBCU ID Camp is your golden opportunity. From 8 am to 5 pm on November 11-12, Houston Sports Park will transform into a hub for aspiring male and female soccer players. Coaches from HBCUs across the nation will be present to evaluate, scout, and offer valuable feedback. Moreover, they might even spot the next soccer prodigy to join their collegiate soccer programs. This camp is not just about honing your soccer skills but also a chance to connect with the HBCU soccer community. You’ll learn the ins and outs of what it takes to excel on the field and in the classroom, which is crucial for a college athlete. The HBCU ID Camp is an excellent platform to network with coaches, learn from experienced athletes, and take the first steps toward your college soccer journey. To secure your spot at this incredible event, don’t forget to register [here](insert registration link). Space is limited to 120 participants, so make sure to reserve your place before it’s too late. It’s time to turn your dreams of playing college soccer into a reality.

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